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Related Experiment Video

Updated: Jul 15, 2025

Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
07:22

Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases

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Correlation Between Fundus Autofluorescence Pattern and Retinal Function on Microperimetry in Choroideremia.

Federica E Poli1,2, Imran H Yusuf1,2, Jasleen K Jolly1,2,3

  • 1Nuffield Laboratory of Ophthalmology, University of Oxford, UK.

Translational Vision Science & Technology
|September 29, 2023
PubMed
Summary

In choroideremia patients, retinal sensitivity in smooth autofluorescence zones is preserved, while mottled zones show impaired function. AF imaging patterns correlate with retinal function, offering potential for clinical trials.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Genetics

Background:

  • Choroideremia is a rare genetic disorder affecting the retinal pigment epithelium.
  • Short-wavelength fundus autofluorescence (AF) imaging reveals distinct patterns in affected retinas.
  • The relationship between these AF patterns and retinal function is not well understood.

Purpose of the Study:

  • To investigate the correlation between smooth and mottled autofluorescence patterns and retinal sensitivity in choroideremia patients.
  • To compare retinal function in these zones between patients and healthy controls.
  • To assess the longitudinal changes in retinal sensitivity over time.

Main Methods:

  • Retrospective analysis of 190 choroideremia patients from two specialist centers.
  • Inclusion of 20 patients with both smooth and mottled AF zones and concurrent mesopic microperimetry.
  • Comparison of mean retinal sensitivities in smooth and mottled zones with age-matched controls.

Main Results:

  • Baseline retinal sensitivity was significantly higher in smooth zones (26.1 dB) versus mottled zones (20.5 dB) in choroideremia patients (P < 0.0001).
  • Smooth zones showed similar retinal sensitivity to controls (P = 0.054), while mottled zones were significantly impaired (P < 0.0001).
  • No significant decline in total sensitivity was observed over 5 years in a small subset of patients.

Conclusions:

  • Retinal sensitivity in choroideremia correlates with autofluorescence patterns: function is preserved in smooth zones but impaired in mottled zones.
  • Autofluorescence patterns may serve as a novel, objective outcome measure in choroideremia clinical trials, reflecting retinal function.