Related Experiment Video

Updated: Jul 15, 2025

Novel Mini-open Transforaminal Lumbar Interbody Fusion
05:52

Novel Mini-open Transforaminal Lumbar Interbody Fusion

Published on: June 6, 2025

100

Reduced volume and altered composition of paraspinal muscles in Marfan syndrome: A retrospective cohort study

Yuichi Yoshida1, Toru Doi2, Hiroyuki Oka3

  • 1Department of Orthopaedic Surgery, The University of Tokyo Hospital, Tokyo, Japan.

Medicine
|September 29, 2023
PubMed

Insights

Patients with Marfan syndrome (MFS) show distinct spinal deformities due to reduced paraspinal muscle size and function compared to idiopathic scoliosis (IS). This study found smaller muscle cross-sectional areas and reduced functional capacity in MFS patients, potentially explaining their unique spinal issues.

Area of Science:

  • Orthopedics
  • Radiology
  • Genetics

Background:

  • Spinal deformities in Marfan syndrome (MFS) differ from idiopathic scoliosis (IS), exhibiting higher progression rates and sagittal malalignment.
  • The underlying causes of these distinct spinal deformities in MFS are not fully understood.

Purpose of the Study:

  • To investigate the characteristics of spinal musculature in patients with MFS.
  • To test the hypothesis that paraspinal muscles in MFS patients differ quantitatively or qualitatively from those in IS patients.

Main Methods:

  • Retrospective cohort study comparing 17 MFS patients (<25 years) with age- and sex-matched IS patients undergoing scoliosis surgery.
  • Preoperative T2-weighted MRI was used to measure relative cross-sectional area (rCSA), fatty infiltration (FI%), and relative functional cross-sectional area (rFCSA) of psoas (PM) and paravertebral muscles (PVM) at L3/4 and L4/5.

Main Results:

  • MFS patients had significantly smaller rCSA of PM at L3/4 and L4/5 compared to IS patients.
  • Higher FI% in PM at L4/5 was observed in the MFS group.
  • Significantly smaller rFCSA of PM (L3/4, L4/5) and PVM (L3/4) were found in MFS patients compared to IS patients.

Conclusions:

  • Marfan syndrome patients exhibit reduced body-size-adjusted cross-sectional area of psoas muscles and diminished body-size-adjusted functional cross-sectional area in both psoas and paravertebral muscles compared to idiopathic scoliosis patients.
  • These muscular differences may contribute to the characteristic spinal deformities observed in Marfan syndrome.

More Related Videos

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies14:10

Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies

Published on: January 31, 2013

33.1K
Preparation of 3D Decellularized Matrices from Fetal Mouse Skeletal Muscle for Cell Culture07:44

Preparation of 3D Decellularized Matrices from Fetal Mouse Skeletal Muscle for Cell Culture

Published on: March 3, 2023

1.4K

Related Concept Videos

Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
2.0K
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
12
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
984
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
21
Fascicle Arrangement in Skeletal Muscles01:25

Fascicle Arrangement in Skeletal Muscles

Fascicles are bundles of muscle fibers in a skeletal muscle. Muscle fascicle arrangement is directly associated with the power and range of motion of various muscles. The configuration of these fascicles can vary, leading to different functional outcomes.
The four primary types of muscle based on fascicle arrangement are:
2.1K