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Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration

Vishnu Dileep1, Carles A Boix2, Hansruedi Mathys1

  • 1Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Cell
|September 29, 2023
PubMed

Keywords:
3D genome organizationAlzheimer’s diseaseDNA double-strand breaksepigenomegenome rearrangementsgenomic mosaicismneurodegenerationsenescencestructural variationstranscriptome

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