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Updated: Jul 15, 2025

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
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Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

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Mechanisms of kidney fibrosis and routes towards therapy

Noriyuki Yamashita1, Rafael Kramann2

  • 1Department of Nephrology and Clinical Immunology, RWTH Aachen University, Aachen, Germany; Department of Nephrology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Trends in Endocrinology and Metabolism: TEM
|September 29, 2023
PubMed

Insights

Kidney fibrosis, a common pathway in chronic kidney diseases (CKDs), remains poorly understood. Recent single-cell genomics reveal complex cellular interactions driving fibrosis, offering new therapeutic targets.

Area of Science:

  • Nephrology
  • Genomics
  • Cell Biology

Background:

  • Kidney fibrosis is a common endpoint for chronic kidney diseases (CKDs).
  • Current understanding of fibrosis mechanisms is incomplete, hindering antifibrotic therapy development.
  • No targeted antifibrotic therapies for the kidney have been approved.

Purpose of the Study:

  • To review key mechanisms driving kidney fibrosis.
  • To highlight recent advances in understanding fibrosis initiation and progression.
  • To explore potential routes for novel targeted antifibrotic therapeutics.

Main Methods:

  • Review of recent single-cell genomic studies in mouse and human models.
  • Analysis of cellular heterogeneity and differentiation processes.
  • Examination of crosstalk mechanisms between kidney cells.

Main Results:

  • Single-cell genomics provide novel insights into kidney fibrosis.
  • Identified heterogeneity and differentiation of myofibroblasts.
  • Elucidated roles of injured epithelial and immune cells and their crosstalk.

Conclusions:

  • Understanding complex cellular crosstalk is crucial for kidney fibrosis.
  • Targeted antifibrotic therapies may emerge from insights into cellular mechanisms.
  • Further research into myofibroblast, epithelial, and immune cell interactions is warranted.
Keywords:
antifibrotic therapeuticscellular crosstalkchronic kidney diseasekidney fibrosissingle-cell RNA sequencingspatial transcriptomics

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