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[Long-term intrathecal isobaric morphine therapy].

Y Gestin, N Peré, C Solassol

Annales Francaises D'Anesthesie Et De Reanimation

|January 1, 1986

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Long-term intrathecal morphine therapy effectively manages cancer pain in 82% of patients. This method, while requiring dosage adjustments due to tolerance, offers a viable option for pain relief.

Area of Science:

Pain Management
Oncology
Pharmacology

Context:

Cancer pain management presents significant challenges, particularly for ambulatory patients.
Intrathecal drug delivery offers a targeted approach to pain relief.

Purpose:

To evaluate the efficacy and safety of long-term intrathecal morphine therapy for cancer pain.
To assess patient outcomes and identify potential complications associated with this treatment modality.

Summary:

A study assessed 121 cancer patients receiving intrathecal morphine via a closed catheter system over a mean of 68 days.
82% of patients achieved good to very good analgesia, despite developing tolerance requiring dose adjustments.
Mechanical complications occurred in a minority of cases, while infections and respiratory depression were rare.

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Impact:

Intrathecal isobaric morphine therapy demonstrates significant potential for effective cancer pain management.
Findings suggest future advancements towards self-administration via implanted pumps.