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Updated: Jul 15, 2025

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
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Metal-Mediated Ligand Affinity Chemistry (MLAC).

Sailajah Gukathasan1, Samuel G Awuah2,3,4

  • 1Department of Chemistry, University of Kentucky, Lexington, KY, USA.

Methods in Molecular Biology (Clifton, N.J.)
|September 29, 2023
PubMed
Summary

Metal-mediated ligand affinity chemistry (MLAC) offers a novel, single-step method for site-specific protein modification. This approach bypasses genetic manipulation, enabling direct chemical modification of endogenous proteins in living systems.

Keywords:
BioconjugationMLACMetal-based covalent modificationProtein modification

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