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Ibuprofen overdose: 126 cases.

A H Hall, S C Smolinske, F L Conrad

    Annals of Emergency Medicine
    |November 1, 1986
    PubMed
    Summary
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    Ibuprofen overdose can cause serious toxicity, particularly in children. Symptoms like CNS depression and seizures were observed, with pediatric patients showing severe effects at higher doses.

    Area of Science:

    • Toxicology
    • Pharmacology
    • Pediatric Emergency Medicine

    Background:

    • Ibuprofen is a common over-the-counter nonsteroidal anti-inflammatory drug (NSAID).
    • Overdose cases can lead to significant adverse effects, necessitating a clear understanding of toxicity thresholds.

    Purpose of the Study:

    • To investigate the clinical manifestations and dose-response relationship of ibuprofen overdose.
    • To identify risk factors and toxicity patterns in pediatric and adult populations.

    Main Methods:

    • Retrospective analysis of ibuprofen overdose cases.
    • Correlation of ingested dose (mg/kg) with observed symptoms and outcomes.
    • Comparison of symptomatic versus asymptomatic groups in children and adults.

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    Main Results:

    • 19% of patients (24/126) developed symptoms, with higher incidence in adults (47%) than children (7%).
    • Pediatric patients who became symptomatic ingested a mean of 440 mg/kg, significantly higher than asymptomatic children (114 mg/kg).
    • No symptoms were reported below 99 mg/kg ingestion; serious toxicity, including seizures, apnea, and one fatality, occurred in children.

    Conclusions:

    • Ibuprofen overdose can lead to severe toxicity, especially in pediatric populations.
    • A dose of <99 mg/kg appears safe, while higher ingestions warrant close monitoring.
    • Early recognition and understanding of dose-dependent toxicity are crucial for managing ibuprofen overdose.