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Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
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Sexual dysfunction in women with PCOS: a case control study.

H Pastoor1, S Both2, E T M Laan2

  • 1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus University Medical Centre, Rotterdam, The Netherlands.

Human Reproduction (Oxford, England)
|September 30, 2023
PubMed
Summary
This summary is machine-generated.

Women with polycystic ovary syndrome (PCOS) experience more sexual dysfunction and distress. However, sex steroid levels show minimal direct impact on sexual function in these women.

Keywords:
FSDS-RFSFIandrogenspolycystic ovary syndromesexuality

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Area of Science:

  • Reproductive Endocrinology
  • Sexual Medicine
  • Endocrinology

Background:

  • Women with polycystic ovary syndrome (PCOS) report lower sexual function and satisfaction, alongside increased sexual distress.
  • Factors contributing to this include obesity, hirsutism, acne, infertility, anxiety, and depression.
  • The relationship between hyperandrogenism, common in PCOS, and sexual function remains inconclusive.

Purpose of the Study:

  • To investigate the relationship between sex steroid levels and sexual function in women with and without PCOS.
  • To compare sexual function and distress levels between women with PCOS and controls.

Main Methods:

  • An observational prospective case-control study involving 135 women (68 with PCOS, 67 controls) aged 18-40.
  • Participants underwent extensive medical and endocrine screening, including mass spectrometry and validated sexual function questionnaires.
  • Data were collected between March 2017 and March 2020.

Main Results:

  • Women with PCOS reported significantly lower sexual function (FSFI), higher sexual distress (FSDS-R), and higher rates of sexual dysfunction and clinical sexual distress compared to controls.
  • Regression analyses revealed few and weak associations between androgen levels and sexual function, explaining a maximum of 15% of the variance.
  • While group-hormone interactions were significant, separate analyses showed no significant associations in the PCOS group; the control group showed weak negative associations between certain androgens and sexual function parameters.

Conclusions:

  • Sexual function is impaired in women with PCOS, but endocrine factors appear to have a minimal direct impact.
  • Clinical care for women with PCOS should address sexuality and offer psychosexual counseling.