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Metformin Improves the Prerequisites for FGF21 Signaling in Patients With Type 2 Diabetes.

Anne Kathrine Nissen Pedersen1, Lars Christian Gormsen2, Søren Nielsen3,4

  • 1Medical/Steno Aarhus Research Laboratory, Department of Clinical Medicine, Aarhus University, 8200 Aarhus N, Denmark.

The Journal of Clinical Endocrinology and Metabolism
|September 30, 2023
PubMed
Summary

Metformin treatment in type 2 diabetes patients reduced fibroblast activation protein (FAP) activity and enhanced FGF21 signaling in adipose tissue by upregulating FGFR1c and β-klotho. This suggests improved peripheral FGF21 sensitivity with metformin therapy.

Keywords:
fibroblast activation protein (FAP)fibroblast growth factor 21 (FGF21)metformintype 2 diabetes (T2D)

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