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Firmicutes is a diverse phylum of Gram-positive bacteria characterized by a low GC content in their genomes. This phylum includes organisms with monoderm or diderm cell envelopes, highlighting a complex evolutionary history. Firmicutes comprises several major orders, including Lactobacillales, Clostridiales, and Bacillales, which exhibit remarkable diversity in their morphology, metabolism, and ecological roles.The order Lactobacillales includes lactic acid bacteria, which are fermentative...
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Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
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Updated: Jul 15, 2025

The Cultivation, Growth, and Viability of Lactic Acid Bacteria: A Quality Control Perspective
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Lactococcus lactis, a bacterium with probiotic functions and pathogenicity.

Fan Wu1, Xinmei Xie2, Tao Du1

  • 1College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China.

World Journal of Microbiology & Biotechnology
|September 30, 2023
PubMed
Summary

Lactococcus lactis (L. lactis), a safe probiotic, is increasingly linked to animal and human infections like mastitis. This review examines L. lactis characteristics and diversity amidst its dual role as a beneficial microbe and pathogen.

Keywords:
Lactococcus lactisMastitisSafe

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Area of Science:

  • Microbiology
  • Veterinary Medicine
  • Food Science

Background:

  • Lactococcus lactis (L. lactis) is a key lactic acid bacterium (LAB) recognized for safe use in animal gut health and immunity.
  • Commercially vital in feed, fermentation, and vaccines, L. lactis is also increasingly isolated from clinical infections in fish, birds, cattle, and humans.
  • While historically used as a dairy probiotic, L. lactis is now implicated in bovine mastitis, posing a significant challenge due to poorly understood pathogenesis.

Conclusions:

  • The pathogenic potential of L. lactis, particularly in bovine mastitis, requires further investigation.
  • Understanding L. lactis diversity is crucial for differentiating beneficial strains from pathogenic ones.
  • This review highlights the need for updated strategies in managing L. lactis in animal husbandry and clinical settings.