Related Experiment Video
Updated: Jul 15, 2025
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
MicroRNAs and colorectal cancer: clinical potential and regulatory networks
George Yiadom Osei1,2, Joseph Adu-Amankwaah3, Selina Koomson2
1Department of Biomedical Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Pulau Pinang, 13200, Malaysia.
Abstract:
Colorectal cancer (CRC) is a serious global health concern, with a high incidence and mortality rate. Although there have been advancements in the early detection and treatment of CRC, therapy resistance is common. MicroRNAs (miRNAs), a type of small non-coding RNA that regulates gene expression, are key players in the initiation and progression of CRC. Recently, there has been growing attention to the complex interplay of miRNAs in cancer development. miRNAs are powerful RNA molecules that regulate gene expression and have been implicated in various physiological and pathological processes, including carcinogenesis. By identifying current challenges and limitations of treatment strategies and suggesting future research directions, this review aims to contribute to ongoing efforts to enhance CRC diagnosis and treatment. It also provides a comprehensive overview of the role miRNAs play in CRC carcinogenesis and explores the potential of miRNA-based therapies as a treatment option. Importantly, this review highlights the exciting potential of targeted modulation of miRNA function as a therapeutic approach for CRC.
Insights
Colorectal cancer (CRC) therapy resistance is a major challenge. This review explores microRNAs (miRNAs) roles in CRC and their potential for novel, targeted therapies.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Colorectal cancer (CRC) presents a significant global health burden with high incidence and mortality.
- Despite advances in early detection and treatment, therapeutic resistance remains a common obstacle in CRC management.
- MicroRNAs (miRNAs), small non-coding RNAs regulating gene expression, are increasingly recognized for their critical roles in CRC initiation and progression.
Purpose of the Study:
- To provide a comprehensive overview of the involvement of miRNAs in colorectal cancer carcinogenesis.
- To identify current challenges and limitations in existing CRC treatment strategies.
- To explore the therapeutic potential of miRNA-based interventions for colorectal cancer.
Main Methods:
- Literature review focusing on the role of microRNAs in colorectal cancer.
- Analysis of current therapeutic strategies and their limitations.
- Exploration of emerging miRNA-targeted therapies.
Main Results:
- MicroRNAs are integral to the complex molecular mechanisms driving colorectal cancer development and progression.
- Dysregulation of specific miRNAs contributes to therapy resistance in CRC.
- Targeted modulation of miRNA function presents a promising avenue for novel CRC treatments.
Conclusions:
- MicroRNAs are crucial regulators in colorectal cancer and represent viable therapeutic targets.
- Understanding miRNA pathways can lead to improved diagnostic and treatment strategies for CRC.
- MiRNA-based therapies hold significant potential for overcoming treatment resistance and improving patient outcomes in colorectal cancer.
