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Updated: Jul 15, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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Affimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition

Heather L Martin1, Amy L Turner2, Julie Higgins3

  • 1BioScreening Technology Group, Leeds Institutes of Molecular Medicine, University of Leeds, Leeds LS9 7TF, UK; Division of Molecular Medicine, Leeds Institute of Medical Research at St James's University Hospital, University of Leeds, Leeds LS9 7TF, UK; School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.

Cell Reports
|September 30, 2023
PubMed

Keywords:
AffimerCP: Cell biologyPAK5high-content screeningkinasesignalingstructural biologyurothelial cancer

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