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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

Impact of carotid hemodynamics on carotid plaque location: Age difference

Xia Ren¹, Fan Su¹, Jian Hu¹

¹School of Public Health, Wannan Medical College, Wuhu, Anhui Province, China.

Neuro Endocrinology Letters

|September 30, 2023

Insights

Carotid artery blood flow velocity and resistance index influence plaque location. Specific hemodynamic indexes like RICA S/D and LCCA S/D are risk factors for plaque in different carotid locations, while others offer protection.

Area of Science:

Vascular Medicine
Cardiovascular Imaging
Medical Diagnostics

Background:

Carotid artery plaque location is influenced by various factors.
Understanding hemodynamic influences is crucial for risk stratification.

Purpose of the Study:

To investigate how carotid hemodynamics in the common carotid artery (CCA) and internal carotid artery (ICA) affect carotid plaque location.
To identify specific hemodynamic parameters associated with different plaque distributions.

Main Methods:

Doppler ultrasound was used to assess carotid plaque location in 4444 participants.
Patients were categorized into LEFT, RIGHT, BOTH, and NONE plaque location groups.
Multiple logistic regression and smooth curve analysis determined relationships between hemodynamic indexes and plaque location.

Main Results:

Right internal carotid artery (RICA) systolic/diastolic velocity ratio (S/D) and left common carotid artery (LCCA) S/D were identified as risk factors for plaque in specific locations.
Right internal carotid artery resistance index (RICA RI) was a protective factor for bilateral plaques (BOTH group).
Age-stratified analysis revealed different hemodynamic risk and protective factors for plaque location in younger (<52) and older (>52) participants.

Conclusions:

Carotid hemodynamics significantly influence carotid plaque location.
Specific hemodynamic indexes serve as risk or protective factors for plaque distribution in the CCA and ICA.
Age is a modifying factor in the relationship between carotid hemodynamics and plaque location.

Read full analysis

Abstract

Purpose:

This study was aimed to investigate the influence of carotid hemodynamics in common carotid artery (CCA) and internal carotid artery (ICA) on carotid plaque location.

Methods:

A total of 4444 participants from Anhui Maanshan People's Hospital were selected from December 2013 to December 2018. Doppler ultrasound was used to measure the location of carotid plaque. Patients were divided into four groups according to plaque location: LEFT, RIGHT, BOTH, and NONE. Multiple logistic regression and smooth curve were applied to determine the relationship of carotid plaque location and hemodynamic indexes.

Results:

Compared with the NONE group, the ratio of artery systolic and diastolic blood flow velocity in right internal carotid (RICA S/D) was a risk factor for LEFT group (OR=1.548) after adjustment; artery systolic and diastolic blood flow velocity ratio of left common carotid artery (LCCA S/D) was a risk factor for RIGHT group (OR=1.250); resistance index of right internal carotid (RICA RI) was a protective factor for BOTH group (OR=0.097), while LCCA S/D and RICA S/D were risk factors for BOTH group (OR=1.201, OR=1.457). Compared with the RIGHT group, artery systolic and diastolic blood flow velocity ratio of right common carotid (RCCA S/D) was the risk factor for the LEFT group (OR=1.463), LCCA S/D and RICA S/D were the risk factors for BOTH group (OR=1.706, OR=2.111). After age stratification, resistance index of right common carotid artery (RCCA RI) and resistance index of left internal carotid artery (LICA RI) were protective factors for BOTH group (OR=0.046, OR=0.042) in group younger than 52. RCCA S/D and RICA S/D were risk factors for BOTH group (OR=1.557, OR=1.843). Resistance index of left common carotid artery (LCCA RI) was a protective factor in the LEFT group compared with the RIGHT group (OR=0.476). In group older than 52, RICA S/D was a risk factor for LEFT group (OR=1.388). LCCA S/D was a risk factor for RIGHT group (OR=1.575). LCCA S/D and RICA S/D were risk factors for BOTH group (OR=1.348, OR=1.311). RICA S/D and RCCA S/D were protective factors in the LEFT group compared with the RIGHT group (OR=0.567, OR=0.680).

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