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The role of CDR1as/ciRS-7 in cardio-cerebrovascular diseases

Yingchun Shao1, Jiazhen Xu1, Bing Liang1

  • 1The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute, Qingdao 266071, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|September 30, 2023
PubMed

Insights

Cerebellar degeneration-related protein 1 antisense RNA (CDR1as), or ciRS-7, is increasingly recognized for its role in cardio-cerebrovascular diseases. This review summarizes CDR1as

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Cerebellar degeneration-related protein 1 antisense RNA (CDR1as), also known as ciRS-7, is a notable circular RNA.
  • Initially studied for its role in cancer, CDR1as is now recognized for its involvement in cardio-cerebrovascular diseases.

Purpose of the Study:

  • To comprehensively review the biological characteristics, regulatory mechanisms, and roles of CDR1as in cardio-cerebrovascular diseases.
  • To provide insights into the potential mechanisms of CDR1as in these diseases.

Main Methods:

  • Literature review of recent studies on CDR1as and cardio-cerebrovascular diseases.
  • Analysis of signal transduction pathways related to inflammatory response and oxidative stress.

Main Results:

  • CDR1as plays a unique role in the occurrence of cardio-cerebrovascular diseases.
  • CDR1as is linked to pathways involving inflammatory response and oxidative stress, suggesting potential mechanisms.

Conclusions:

  • CDR1as is a potential therapeutic and diagnostic target for cardio-cerebrovascular diseases.
  • Further research is needed to fully elucidate the mechanisms and therapeutic potential of CDR1as.
Keywords:
CDR1asCardiovascular diseasesCerebellar degeneration-related protein 1 antisense RNACerebrovascular diseasesCiRS-7

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