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Related Concept Videos

Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

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The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
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Autoimmune Disorders01:29

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Autonomic Nervous System01:22

Autonomic Nervous System

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The autonomic nervous system (ANS) is a critical component of the peripheral nervous system, primarily responsible for regulating involuntary bodily functions and maintaining homeostasis. It functions in tandem with the central nervous system (CNS) to seamlessly coordinate various physiological processes without the need for conscious control.
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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Updated: Jul 15, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Autonomic dysfunction in systemic sclerosis: A scoping review.

Marco Di Battista1, Christopher W Wasson2, Begonya Alcacer-Pitarch3

  • 1Rheumatology Unit, University of Pisa, Pisa, Italy; Department of Medical Biotechnologies, University of Siena, Siena, Italy.

Seminars in Arthritis and Rheumatism
|September 30, 2023
PubMed
Summary
This summary is machine-generated.

Autonomic nervous system (ANS) dysfunction is strongly linked to systemic sclerosis (SSc). This review maps current research on ANS involvement in SSc pathogenesis, clinical signs, and diagnostics, guiding future studies.

Keywords:
Autonomic dysfunctionAutonomic nervous systemNeurotrophinsSystemic sclerosis

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Area of Science:

  • Rheumatology
  • Neurology
  • Cardiology

Background:

  • Systemic sclerosis (SSc) is increasingly linked to autonomic nervous system (ANS) pathology.
  • The precise relationship between autonomic dysfunction and SSc pathogenesis remains unclear.
  • Understanding ANS involvement is crucial for SSc patient management.

Purpose of the Study:

  • To conduct a scoping review of existing research on ANS involvement in SSc.
  • To map the current evidence regarding the pathogenesis, clinical presentation, and diagnostic tools for dysautonomia in SSc.
  • To identify gaps and inform future research directions.

Main Methods:

  • A comprehensive literature search was performed using MEDLINE and Web of Science databases.
  • Studies focusing on dysautonomia in SSc, including pathogenesis, clinical aspects, and diagnostics, were included.
  • Data from 109 selected studies involving 2742 SSc patients were analyzed.

Main Results:

  • The cardiovascular system, particularly heart rate variability, was the most studied aspect.
  • Evidence of dysautonomia was also found in digital vasculopathy, gastrointestinal system, and SSc skin.
  • Hypotheses regarding sympathetic system-ischemia and neurotrophins were discussed.

Conclusions:

  • A significant influence of ANS deregulation on SSc is evident in the current literature.
  • The review synthesizes available evidence on the pathogenesis, clinical presentation, and diagnosis of SSc-related dysautonomia.
  • Further research is necessary to elucidate the mechanisms and temporal aspects of autonomic dysfunction in SSc.