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Updated: Jul 15, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Nrf2 protein in melanoma progression, as a new means of treatment
Qun Feng1, Xiaolin Xu2, Shoulin Zhang3
1College of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, 130017, China.
Abstract:
Melanoma is a potentially lethal form of skin cancer resulting from the unlimited proliferation of melanocytes. Melanocytic lineage appears to have a greater rate of reactive oxygen species (ROS) production, possibly as a result of exposure to ultraviolet (UV) light and the production of melanin. It has been established that nuclear factor erythroid 2-related factor 2 (Nrf2) serves as a master regulator of the cellular response to oxidative stresses. Recent research has shown that the Nrf2 and its critical negative regulator Kelch-like ECH-associated protein 1 (Keap1) are misregulated in melanoma, and the Keap1-Nrf2 pathway has emerged as a promising new target for treating and preventing melanoma. In melanoma, Nrf2 may either limit tumor growth or promote its development. This review covers a wide range of topics, including the dual functions played by the Keap1-Nrf2 signaling pathway in melanoma and the most recent targeting techniques of the Nrf2.
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