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Development of a silicone-based radio-fluorogenic dosimeter using dihydrorhodamine 6G.

Takuya Maeyama1, Kiichiro Hayashi2, Yusuke Watanabe3

  • 1Department of Chemistry, School of Science, Kitasato University, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa 252-0373, Japan; RIKEN Nishina Center for Accelerator-Based Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
|October 1, 2023
PubMed
Summary

A new flexible, container-less silicon dosimeter uses a dihydrorhodamine 6G (DHR6G) fluorescence probe. This DHR6G-silicon elastomer (DHR6G-SE) shows linear dose response and stable sensitivity for radiation therapy quality assurance.

Keywords:
Dose responseFluorescence probeGel dosimetrySilicon dosimeterStabilitySynchrotron X-ray

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Area of Science:

  • Medical Physics
  • Materials Science
  • Radiochemistry

Background:

  • Flexible, container-less silicon dosimeters are crucial for image-guided and adaptive radiation therapy.
  • Existing dosimeters require enhancements for motion and deformation tracking during treatment.
  • Radiosensitive compounds are needed to improve dosimeter accuracy and applicability.

Purpose of the Study:

  • To develop a novel, container-less, free-shape silicon dosimeter using a fluorescence probe.
  • To synthesize and optimize a dihydrorhodamine 6G-silicon elastomer (DHR6G-SE) for radiation dosimetry.
  • To assess the DHR6G-SE's performance, including dose response, stability, and suitability for low-energy X-ray dosimetry.

Main Methods:

  • A cost-effective synthesis method for DHR6G-SE was developed and optimized.
  • Compositional parameters, including DHR6G concentration, pyridine, and silicone elastomer ratios, were fine-tuned.
  • Fluorescence intensity was measured against absorbed radiation dose (0-8 Gy) and stability was assessed over 64 hours.

Main Results:

  • Optimized DHR6G-SE (2.2 × 10⁻³ wt% DHR6G, 0.024 wt% pyridine, SILPOT 184 SE base/curing agent = 10/1) demonstrated a linear fluorescence increase with absorbed dose.
  • The DHR6G-SE exhibited highly stable sensitivity for up to 64 hours.
  • The potential for dosimetry of low-energy X-rays using the container-less DHR6G-SE was investigated.

Conclusions:

  • The developed DHR6G-SE offers a promising new radiosensitive material for flexible, container-less 3D dosimetry.
  • This material shows excellent linear dose response and stability, suitable for radiation therapy quality assurance applications.
  • Further investigation into low-energy X-ray dosimetry applications is warranted.