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Assessment of neonatal platelet function using a viscoelastic technique.

C Blifeld, J T Courtney, J R Gross

    Annals of Clinical and Laboratory Science
    |September 1, 1986
    PubMed
    Summary

    The Sonoclot analyzer assesses plasma viscoelasticity and platelet function in newborns. Cord blood showed faster clotting than adults, while premature infants had reduced platelet function compared to cord blood.

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    Area of Science:

    • Neonatal Hematology
    • Hemostasis and Thrombosis
    • Medical Device Technology

    Background:

    • The Sonoclot is a viscoelastometer measuring plasma viscoelastic changes upon recalcification.
    • Platelet-rich plasma (PRP) and platelet-poor plasma (PPP) yield distinct Sonoclot tracings.
    • Assessing neonatal hemostasis is crucial due to unique physiological differences.

    Purpose of the Study:

    • To evaluate coagulability and platelet function in newborn cord blood and premature infant blood using the Sonoclot.
    • To compare these neonatal hemostatic parameters with adult control values.

    Main Methods:

    • Sonoclot analysis was performed on PRP from 53 normal term newborn cord bloods.
    • Whole blood from 17 very low birth weight premature infants was also analyzed.

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  • Results were compared between neonatal groups and with established adult control data.

    • Main Results:

    • Newborn cord PRP samples exhibited shorter time-related parameters than adult controls.
    • Premature infant values suggested diminished platelet function relative to cord blood samples.
    • Premature infant hemostatic parameters were comparable to adult control values.

    Conclusions:

    • The Sonoclot technique effectively assesses neonatal hemostasis and platelet function.
    • Neonatal hemostasis differs from adult patterns, with variations between term and premature infants.
    • This method offers advantages for neonatal studies, requiring small sample volumes and minimizing infant manipulation.