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Updated: Jul 15, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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Regiocontrol Using Fluoro Substituent on 3,6-Disubstituted Arynes

Eito Yoshioka1, Yousuke Yamaoka1, Shunsuke Shimada1

  • 1School of Pharmacy and Department of Pharmacy, Hyogo Medical University.

Chemical & Pharmaceutical Bulletin
|October 1, 2023
PubMed
Summary

The study investigated how fluorine substituents influence the regioselectivity of 3,6-disubstituted aryne reactions. Fluorine and bromine substituents enabled high regiocontrol in cycloaddition and insertion reactions.

Keywords:
arynearyne precursorfluorine atomregioselectivity

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