Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Noncanonical association of EZH2 with E2F1 promotes tumor proliferation through chromatin remodeling.

Experimental & molecular medicine·2025
Same author

Gut microbiota and brain-resident CD4<sup>+</sup> T cells shape behavioral outcomes in autism spectrum disorder.

Nature communications·2025
Same author

Perturbed cell fate decision by schizophrenia-associated AS3MT<sup>d2d3</sup> isoform during corticogenesis.

Science advances·2025
Same author

The capicua-ataxin-1-like complex regulates Notch-driven marginal zone B cell development and sepsis progression.

Nature communications·2024
Same author

Regulatory RNA: from molecular insights to therapeutic frontiers.

Experimental & molecular medicine·2024
Same author

A <i>cis</i>-regulatory lexicon of DNA motif combinations mediating cell-type-specific gene regulation.

Cell genomics·2023
Same journal

In-depth multimodal validation of <sup>18</sup>F-THK5351 for imaging monoamine oxidase-B-mediated reactive astrogliosis in Alzheimer's and related neurodegenerative diseases.

Experimental & molecular medicine·2026
Same journal

Exercise-stimulated primary cilia on preosteoclasts promote periosteal-bone formation.

Experimental & molecular medicine·2026
Same journal

Therapeutic effect of intranasal nicotinamide adenine dinucleotide in the restoration of olfactory dysfunction.

Experimental & molecular medicine·2026
Same journal

Metabolic reprogramming of myeloid cells in cancer: from lactate-NAMPT axis to AI-guided therapeutics.

Experimental & molecular medicine·2026
Same journal

Coordinated DNA 5-mC and RNA m<sup>5</sup>C methylation epigenetically regulates MZF1 splice variants to drive EGFR-TKI resistance.

Experimental & molecular medicine·2026
Same journal

Retraction Note: Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells.

Experimental & molecular medicine·2026
See all related articles

Related Experiment Video

Updated: Jul 15, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

5.0K

Spatial transcriptomics in neuroscience.

Namyoung Jung1, Tae-Kyung Kim2,3

  • 1Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk, 37673, Republic of Korea.

Experimental & Molecular Medicine
|October 1, 2023
PubMed
Summary
This summary is machine-generated.

Spatial transcriptomics (ST) reveals brain cell types and their spatial organization, overcoming limitations of single-cell RNA sequencing (scRNA-seq). This technology enhances understanding of neural circuits and brain function.

More Related Videos

Author Spotlight: Integrating Organoid Models with Single-Cell and Spatial Transcriptomics Technologies
05:45

Author Spotlight: Integrating Organoid Models with Single-Cell and Spatial Transcriptomics Technologies

Published on: March 29, 2024

2.4K
Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics
07:43

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

Published on: May 3, 2024

2.8K

Related Experiment Videos

Last Updated: Jul 15, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

5.0K
Author Spotlight: Integrating Organoid Models with Single-Cell and Spatial Transcriptomics Technologies
05:45

Author Spotlight: Integrating Organoid Models with Single-Cell and Spatial Transcriptomics Technologies

Published on: March 29, 2024

2.4K
Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics
07:43

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

Published on: May 3, 2024

2.8K

Area of Science:

  • Neuroscience
  • Genomics
  • Molecular Biology

Background:

  • The brain's complexity arises from diverse cell types with unique functional connectivity.
  • Single-cell RNA sequencing (scRNA-seq) identifies cell types but lacks spatial context.
  • Understanding cell configurations and connectivity is crucial for brain function.

Purpose of the Study:

  • To review spatial transcriptomics (ST) tools and their applications in neuroscience.
  • To highlight how ST integrates single-cell identity with spatial information.
  • To discuss insights gained into brain organization and neural circuits.

Main Methods:

  • Review of various spatial transcriptomics (ST) technologies developed over the past decade.
  • Integration of imaging and sequencing-based approaches for spatial gene expression analysis.
  • Correlation of single-cell transcriptomic data with spatial localization in brain tissue.

Main Results:

  • Spatial transcriptomics enables mapping of cell-type organization within the brain.
  • ST tools provide high-resolution insights into neural circuit properties.
  • Functional brain atlases are being created using ST data.

Conclusions:

  • Spatial transcriptomics is essential for understanding cell-type contributions to brain function.
  • ST overcomes the spatial limitations of scRNA-seq for comprehensive brain analysis.
  • These tools offer unprecedented insights into the brain's intricate structure and function.