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To Tip or Not to Tip: A New Combination for Precision Medicine in Head and Neck Cancer

Rex H Lee1, Daniel E Johnson1, Jennifer R Grandis1

  • 1Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, San Francisco, California.

Cancer Research
|October 2, 2023
PubMed

Insights

Targeted therapy for head and neck squamous cell carcinoma (HNSCC) shows promise. Combination therapy with alpelisib and tipifarnib effectively inhibited mTOR in preclinical models, offering hope for PIK3CA/HRAS-dysregulated HNSCC patients.

Area of Science:

  • Oncology
  • Translational Research
  • Cancer Therapeutics

Background:

  • Advances in targeted therapy for head and neck squamous cell carcinoma (HNSCC) are hindered by a lack of effective preclinical models.
  • Developing robust models is crucial for advancing translational research in HNSCC.

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