Microneedle systems: cell, exosome, and nucleic acid based strategies

Area of Science:

• Biomedical Engineering
• Drug Delivery Systems
• Nanotechnology

Background:

• Cells, exosomes, and nucleic acids are crucial in biomedical engineering but face challenges like immunogenicity and instability.
• Microneedle (MN) technology provides a versatile and minimally invasive approach to overcome these limitations.

Purpose of the Study:

• To provide a comprehensive review of microneedle technology for cell, exosome, and nucleic acid applications.
• To highlight current applications, research challenges, and future prospects in this rapidly evolving field.

Main Methods:

• Literature review of microneedle technology advancements.
• Analysis of current applications in cell-, exosome-, and nucleic acid-based systems.
• Discussion of prevailing research challenges and future directions.

Main Results:

• Microneedles are an ideal platform for the extraction, storage, and delivery of biological components.
• Current MN systems demonstrate significant potential in overcoming drawbacks of traditional methods.
• Key challenges include scalability, stability, and clinical translation.

Conclusions:

• Microneedle technology holds immense promise for advancing the clinical application of cells, exosomes, and nucleic acids.
• Further research is needed to address existing challenges and facilitate widespread adoption.
• MNs offer a transformative approach to biomedical engineering and drug delivery.