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Validation of AI-based software for objectification of conjunctival provocation test.

Yury Yarin1, Alexandra Kalaitzidou1, Kira Bodrova1

  • 1Practice for ENT und Allergology, Dresden, Germany.

The Journal of Allergy and Clinical Immunology. Global
|October 2, 2023
PubMed
Summary

A new AI tool, AllergoEye, objectively quantifies allergic reactions during conjunctival provocation tests (CPT). This method offers high sensitivity and specificity, improving allergy diagnosis and therapy control.

Keywords:
Allergyartificial intelligence (AI)conjunctival provocation testdeep learning

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Area of Science:

  • Allergology
  • Medical technology
  • Artificial intelligence in medicine

Background:

  • Provocation tests are vital in allergology for assessing allergen sensitivity.
  • Objective quantification of allergic reactions is crucial but often lacking.
  • The conjunctival provocation test (CPT) is underutilized due to a lack of objective measurements.

Purpose of the Study:

  • To develop and validate AllergoEye, an AI-based method for quantitative evaluation of conjunctival allergic reactions.
  • To address the limitations of subjective assessments in CPT.

Main Methods:

  • AllergoEye utilizes a smartphone camera for imaging and a PC for AI-driven image analysis.
  • A clinical study involved 41 patients undergoing standardized CPT with grass allergens.
  • Reactions were assessed using both subjective symptom scores and quantitative AllergoEye scores.

Main Results:

  • AllergoEye achieved 98% sensitivity and 90% specificity compared to human evaluation.
  • Adjusting thresholds improved AllergoEye's specificity to 97%.
  • A significant correlation was found between AllergoEye's quantified sensitivity and specific IgE levels, unlike subjective scores.

Conclusions:

  • AllergoEye is a sensitive and efficient tool for objective measurement of allergic reactions in CPT.
  • The AI method is suitable for both clinical research and routine patient therapy control.
  • Objective quantification enhances the reliability and utility of CPT in allergy management.