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Chronic kidney disease in children: an update
Luigi Cirillo1,2, Letizia De Chiara2, Samantha Innocenti1
1Nephrology and Dialysis Unit, Meyer Children's Hospital IRCCS, Florence, Italy.
Clinical Kidney Journal
|October 2, 2023
Summary
Pediatric chronic kidney disease (CKD) is underdiagnosed due to challenges in definition. Advances in genetic sequencing suggest CKD is more common in children and adolescents than previously thought.
Area of Science:
- Nephrology
- Pediatric Nephrology
- Genetics
Background:
- Chronic kidney disease (CKD) is a significant global health concern.
- Accurate prevalence and consistent information on pediatric CKD are lacking.
- Current CKD definitions based on GFR and albuminuria are challenging in children due to age-related physiological changes, leading to underdiagnosis and delayed management.
Purpose of the Study:
- To review recent innovations in pediatric CKD.
- To provide a new perspective on CKD in children and adolescents.
- To highlight how advances in knowledge can improve diagnosis and management.
Main Methods:
- Review of recent literature on pediatric CKD.
- Focus on advances in understanding epidemiology and causes.
- Emphasis on the impact of massive-parallel sequencing technology.
Main Results:
- Massive-parallel sequencing has revised the understanding of CKD causes in children.
- Evidence suggests pediatric CKD is more frequent than currently reported.
- New knowledge is emerging on molecular pathways and cellular responses to kidney damage.
Conclusions:
- Advances in genetic technologies are crucial for a better understanding of pediatric CKD.
- Improved diagnostic criteria and management strategies are needed for children and adolescents.
- Future research will focus on identifying novel therapeutic targets for pediatric CKD.
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