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Changing demography of trisomy 18
Archives of Disease in Childhood
|October 1, 1986
Summary
Trisomy 18 (Edwards syndrome) affects 1 in 3086 births in Leicestershire. Survival rates are low, with a median of 2.5 days, and many affected infants are born via caesarean section.
Area of Science:
- Medical Genetics
- Perinatal Epidemiology
- Congenital Anomalies
Background:
- Trisomy 18 (Edwards syndrome) is a severe chromosomal disorder.
- Understanding its incidence and outcomes is crucial for perinatal care.
Purpose of the Study:
- To determine the incidence of Trisomy 18 in Leicestershire between 1980-1985.
- To analyze delivery methods and survival periods for infants with Trisomy 18.
Main Methods:
- Retrospective analysis of birth data from Leicestershire.
- Inclusion criteria: infants diagnosed with Trisomy 18 during 1980-1985.
Main Results:
- The incidence of Trisomy 18 was 1 in 3086 births.
- Eleven of 21 affected infants were delivered via caesarean section.
- Median survival was 2.5 days; mean survival was 22 days.
Conclusions:
- Trisomy 18 has a specific incidence rate in the studied population.
- Caesarean section delivery was common among affected infants.
- Survival for Trisomy 18 infants remains critically short.