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Insight into Nrf2: a bibliometric and visual analysis from 2000 to 2022
Yawei Ma1, Zhongqing Wang2, Yuedong Hu1
1Department of Ophthalmology, The First Hospital of China Medical University, Shenyang, China.
Frontiers in Genetics
|October 2, 2023
Summary
This bibliometric analysis reveals a significant global increase in research on Nuclear factor erythroid 2-related factor 2 (Nrf2) and its role in oxidative stress, cancer, and neurological disorders. Future trends focus on novel molecular mechanisms and targeted therapeutic interventions.
Area of Science:
- Biochemistry and Molecular Biology
- Pharmacology and Toxicology
- Genetics and Genomics
Background:
- Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of cellular antioxidant defense.
- Nrf2's role in mitigating oxidative damage and inflammation makes it a key therapeutic target.
- Bibliometric analysis of Nrf2 research is scarce, necessitating a comprehensive overview.
Conclusions:
- China and the US are leading Nrf2 research, with a recent focus on experimental, clinical, and therapeutic aspects.
- Future research will likely explore novel molecular mechanisms (NF-κB, Ho1, Keap1) and targeted Nrf2 modulators.
- Understanding the interplay between Nrf2 and diseases like cancer, metabolic disorders, and neurological conditions is crucial for therapeutic development.
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