Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

27.7K
Overview
27.7K
Hypersensitivities01:30

Hypersensitivities

718
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
718
Cross-reactivity00:42

Cross-reactivity

31.2K
Overview
31.2K
Allergic Drug Reactions01:27

Allergic Drug Reactions

873
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
873
Sputum Studies II: Culture and Sensitivity01:20

Sputum Studies II: Culture and Sensitivity

377
Description
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
377
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic Value of the Meta-Analysis Global Group in Chronic Heart Failure Risk Score in Patients Undergoing Mitral Valve Transcatheter Edge-to-Edge Repair.

Journal of the American Heart Association·2026
Same author

The Japanese Version of 26-Item Informant Questionnaire on Cognitive Decline in the Elderly: Development and Validation Study.

Geriatrics & gerontology international·2026
Same author

Lung-Limited Seronegative Granulomatosis With Polyangiitis Successfully Diagnosed via a Multi-Disciplinary Diagnosis: A Case Report.

The Tokai journal of experimental and clinical medicine·2026
Same author

Transmitral Pressure Gradient and Residual Mitral Regurgitation After Transcatheter Edge-to-Edge Repair in Patients With and Without Hemodialysis.

The American journal of cardiology·2026
Same author

[EOSINOPHIL-ASSOCIATED DISEASES: A PATHOBIOLOGY-BASED, CROSS-ORGAN PERSPECTIVE].

Arerugi = [Allergy]·2026
Same author

One-year clinical remission with tezepelumab in severe asthma: TERESA single-arm prospective study.

The Journal of allergy and clinical immunology·2026

Related Experiment Video

Updated: Jul 15, 2025

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

10.1K

Sensitization pattern to environmental allergens in a Japanese population.

Asako Kitahara1, Yoshiro Yamamoto2, Yuma Fukutomi3

  • 1Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan.

The Journal of Allergy and Clinical Immunology. Global
|October 2, 2023
PubMed
Summary

Japanese adults exhibit distinct allergen sensitization patterns. Three main clusters were identified: nonatopic, house dust mite-dominant, and panatopic, aiding in understanding allergic disease risk.

Keywords:
AllergenIgEcluster analysisfactor analysisgeneral population

More Related Videos

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

16.4K
Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10
10:42

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10

Published on: November 19, 2016

7.6K

Related Experiment Videos

Last Updated: Jul 15, 2025

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

10.1K
Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

16.4K
Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10
10:42

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10

Published on: November 19, 2016

7.6K

Area of Science:

  • Immunology
  • Allergology
  • Population Health

Background:

  • Previous studies established the prevalence of allergen-specific immunoglobulin E (IgE) in Japanese adults.
  • Understanding specific sensitization patterns is crucial for managing allergic diseases.

Purpose of the Study:

  • To elucidate allergen sensitization patterns in a general Japanese adult population.
  • To identify distinct clusters based on allergen-specific IgE profiles.

Main Methods:

  • Serum samples from 800 adult blood donors in Tokyo were analyzed for IgE levels against 23 allergens using ImmunoCAP.
  • Exploratory and confirmatory factor analyses identified relationships among allergen-specific IgE.
  • Hierarchical cluster analysis categorized individuals based on sensitization patterns.

Main Results:

  • Six allergen-specific IgE categories were identified: animals (insects, mites), pollens (Japanese cedar/cypress, alder/grass/weeds), and microorganisms (fungi, skin commensals).
  • Three distinct population clusters emerged: nonatopic, house dust mite-dominant sensitization, and panatopic.
  • The panatopic cluster was further divisible into fungal-sensitized and non-sensitized subgroups.

Conclusions:

  • The Japanese adult population can be stratified into three distinct clusters based on allergen sensitization profiles.
  • These findings provide a framework for understanding allergic airway disease risk in Japan.