Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neighborhood Socioeconomics and Lung Cancer Recurrence and Progression.

Clinical lung cancer·2026
Same author

The 2021 US Preventive Services Task Force Lung Cancer Screening Criteria Miss Many Patients Diagnosed With Early and Late-Stage Lung Cancer: Analysis of 3 Cohort Studies.

Chest·2026
Same author

Assessing Lung Cancer Screening Eligibility of Patients With Lung Cancer in the Boston Lung Cancer Study: An Analysis of 7186 Lung Cancer Cases.

The Annals of thoracic surgery·2025
Same author

Robust fiber orientation distribution function estimation using deep constrained spherical deconvolution for diffusion-weighted magnetic resonance imaging.

Journal of medical imaging (Bellingham, Wash.)·2024
Same author

Leveraging longitudinal diffusion MRI data to quantify differences in white matter microstructural decline in normal and abnormal aging.

bioRxiv : the preprint server for biology·2023
Same author

White matter microstructural metrics are sensitively associated with clinical staging in Alzheimer's disease.

Alzheimer's & dementia (Amsterdam, Netherlands)·2023
Same journal

The Latin American Spanish PACC5 (LAS-PACC5): Advancing Cognitive Assessment in Latinos.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same journal

Obstacles and solutions for implementing amyloid-targeting treatments in Europe.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same journal

Elevated sclerostin levels in cerebrospinal fluid are associated with cognitive impairment in the Alzheimer's disease continuum.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same journal

FTLD-TDP versus LATE-NC: Experience of a Brain Bank specializing in FTLD-TDP.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same journal

Variable Aβ tracer uptake in hyperostosis frontalis interna: implications for brain Aβ PET/CT interpretation.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same journal

Deep contrastive learning framework identifies cell-type-specific drug targets in Alzheimer's disease.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
See all related articles

Related Experiment Video

Updated: Jul 15, 2025

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.5K

Leveraging longitudinal diffusion MRI data to quantify differences in white matter microstructural decline in normal

Derek B Archer1,2, Kurt Schilling3,4, Niranjana Shashikumar1

  • 1Vanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine Nashville Tennessee USA.

Alzheimer'S & Dementia (Amsterdam, Netherlands)
|October 2, 2023
PubMed
Summary
This summary is machine-generated.

White matter microstructural decline occurs in both normal and abnormal aging. However, specific white matter tracts, like the cingulum bundle, show greater vulnerability in abnormal aging processes.

Keywords:
agingdiffusion MRIfree‐waterharmonizationwhite matter

More Related Videos

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

26.3K
Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

12.2K

Related Experiment Videos

Last Updated: Jul 15, 2025

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.5K
Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

26.3K
Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

12.2K

Area of Science:

  • Neuroscience
  • Radiology
  • Gerontology

Background:

  • White matter microstructural integrity is crucial for cognitive function during aging.
  • Distinguishing between normal and abnormal aging trajectories is essential for understanding neurodegeneration.

Purpose of the Study:

  • To investigate differences in white matter microstructural decline between normal and abnormal aging.
  • To identify specific white matter tracts vulnerable to abnormal aging.

Main Methods:

  • Utilized harmonized and free-water corrected diffusion MRI data from longitudinal aging cohorts (ADNI, BLSA, VMAP).
  • Included 1723 participants with 4605 imaging sessions and a mean follow-up of 2.97 years.
  • Assessed differences in white matter microstructural decline in normal versus abnormal aging.

Main Results:

  • A global decline in white matter was observed in both normal and abnormal aging.
  • Specific white matter tracts, including the cingulum bundle, demonstrated increased vulnerability in abnormal aging.
  • The free-water metric highlighted heightened susceptibility in abnormal aging, particularly within the cingulum.

Conclusions:

  • White matter microstructural decline plays a significant role across the aging spectrum.
  • Abnormal aging disproportionately affects certain white matter tracts, suggesting targeted neurodegenerative processes.
  • Future large-scale studies are warranted to further elucidate these age-related neurodegenerative mechanisms.