Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

3.6K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maternal factors associate with microbiota-derived extracellular vesicle profiles in pregnancy: a clinical cohort study.

BMC medicine·2026
Same author

Gut Microbiota-Derived Extracellular Vesicles in Patients With Obesity Undergoing Gastric Bypass Surgery.

Molecular microbiology·2026
Same author

Parental Ability to Identify Severe Illnesses in Their Children.

JAMA network open·2026
Same author

The metabolome of fecal extracellular vesicles in patients with malignant solid tumors.

Scientific reports·2025
Same author

Gut microbiota-derived extracellular vesicles form a distinct entity from gut microbiota.

mSystems·2025
Same author

Gut Mycobiome in Atopic Dermatitis and in Overweight Young Children: A Prospective Cohort Study in Finland.

Journal of fungi (Basel, Switzerland)·2024

Related Experiment Video

Updated: Jul 15, 2025

Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment
10:09

Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment

Published on: June 2, 2020

6.9K

Bacterial extracellular vesicles - brain invaders? A systematic review.

Anna Kaisanlahti1,2, Sonja Salmi3, Sohvi Kumpula1,2

  • 1Biocenter Oulu, University of Oulu, Oulu, Finland.

Frontiers in Molecular Neuroscience
|October 2, 2023
PubMed
Summary

Bacterial extracellular vesicles (EVs) can cross the blood-brain barrier, potentially linking gut microbiota changes to neurodegenerative diseases. More research is needed on EVs from the human gut microbiota.

Keywords:
bacteriablood–brain barrierbrainextracellular vesiclesmicrobiota

More Related Videos

Author Spotlight: Accelerating Research on Bacterial Extracellular Vesicles Separation and Heterogeneity
06:39

Author Spotlight: Accelerating Research on Bacterial Extracellular Vesicles Separation and Heterogeneity

Published on: September 1, 2023

2.7K
Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions
09:36

Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions

Published on: August 26, 2021

3.8K

Related Experiment Videos

Last Updated: Jul 15, 2025

Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment
10:09

Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment

Published on: June 2, 2020

6.9K
Author Spotlight: Accelerating Research on Bacterial Extracellular Vesicles Separation and Heterogeneity
06:39

Author Spotlight: Accelerating Research on Bacterial Extracellular Vesicles Separation and Heterogeneity

Published on: September 1, 2023

2.7K
Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions
09:36

Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions

Published on: August 26, 2021

3.8K

Area of Science:

  • Microbiology
  • Neuroscience
  • Gastroenterology

Background:

  • Gut microbiota dysbiosis is implicated in neurodegenerative diseases.
  • Bacterial extracellular vesicles (EVs) are emerging as key mediators of gut-brain communication.
  • Understanding the role of bacterial EVs in crossing the blood-brain barrier is crucial for deciphering this communication.

Approach:

  • A systematic literature review was conducted using PubMed and Scopus databases.
  • Identified publications focused on bacterial EVs and their passage through the blood-brain barrier.
  • Rigorous screening and exclusion criteria were applied, resulting in 17 reviewed publications.

Key Points:

  • Bacterial EVs have demonstrated the ability to cross the blood-brain barrier.
  • The precise mechanisms of this passage remain largely unelucidated.
  • Limited data currently exists regarding EVs specifically secreted by the human gut microbiota.

Conclusions:

  • This review synthesizes current evidence on bacterial EVs traversing the blood-brain barrier.
  • Highlights the critical need for further investigation into human gut microbiota-derived EVs.
  • Emphasizes the importance of this research for understanding gut-brain axis modulation in neurological conditions.