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Polysaccharides: potential bioactive macromolecules for Alzheimer's disease.
Gong Peng1, Ming Li2, Zhaoli Meng1
1Laboratory of Tumor Immunology, The First Hospital of Jilin University, Changchun, China.
Frontiers in Nutrition
|October 2, 2023
Summary
Polysaccharides (PSs) show promise in treating Alzheimer's disease (AD) by targeting multiple pathological pathways. Further chemical investigation is needed to fully understand their therapeutic potential in AD.
Area of Science:
- Neuroscience
- Biochemistry
- Pharmacology
Background:
- Alzheimer's disease (AD) is a leading cause of death and disability with no current disease-modifying treatments.
- The recent approval of sodium oligomannate highlights the potential of saccharides in AD therapy.
- Understanding the role of saccharides in AD pathogenesis and treatment is crucial.
Purpose of the Study:
- To summarize and explain the role of polysaccharides (PSs) in Alzheimer's disease (AD).
- To review the potential benefits of PSs in alleviating AD pathology and cognitive decline.
Main Methods:
- Literature review of recent studies on polysaccharides and their effects in Alzheimer's disease.
- Analysis of mechanisms by which PSs may counteract AD pathologies.
Main Results:
- Polysaccharides (PSs) demonstrate potential benefits both in vitro and in vivo for Alzheimer's disease.
- PSs may alleviate pathological damage and improve cognitive symptoms by targeting amyloid-beta and tau proteins.
- PSs can also attenuate oxidative stress, reduce inflammation, and promote neuroplasticity.
Conclusions:
- Polysaccharides show potential to address multiple pathological aspects of Alzheimer's disease.
- Further chemical investigation is warranted to fully elucidate the therapeutic applications of PSs in AD.
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