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Bio-inspired microfluidics: A review.
Kiran Raj M1, Jyotsana Priyadarshani2, Pratyaksh Karan3
1Department of Applied Mechanics and Biomedical Engineering, Indian Institute of Technology Madras, Chennai, Tamil Nadu 600036, India.
Biomicrofluidics
|October 2, 2023
Summary
Bio-inspired microfluidics leverage nature's designs for advanced "on-chip" systems. Future research integrates AI and machine learning for personalized disease models and faster drug development.
Area of Science:
- Biomicrofluidics
- Bio-inspired engineering
- Microfluidic systems
Background:
- Biomicrofluidics draws inspiration from natural biological systems.
- Translating biological functionalities into artificial microfluidic systems presents significant challenges.
- Progress requires integrating experimental and simulation approaches at the engineering-biology interface.
Purpose of the Study:
- To review recent advancements in bio-inspired microfluidic systems.
- To discuss the development and applications of "on-chip" technologies.
- To explore future research directions for creating human physiological replicas on biochips.
Main Methods:
- Integration of experimental and computational simulation tools.
- Review of "on-chip" technology development, applications, and fabrication advancements.
- Exploration of data-driven modeling (AI, machine learning) combined with physics-based paradigms.
Main Results:
- Significant progress in bio-inspired microfluidic systems has been achieved.
- "On-chip" technologies and their applications are expanding.
- Advancements in materials and fabrication are enabling more sophisticated systems.
Conclusions:
- Future research should focus on merging AI/ML with physics-based models for realistic human physiological replicas.
- These advanced biochips can revolutionize disease modeling and drug development.
- This approach promises expedited drug screening while minimizing animal and human trials.
