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Updated: Jul 15, 2025

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Bio-inspired microfluidics: A review.

Kiran Raj M1, Jyotsana Priyadarshani2, Pratyaksh Karan3

  • 1Department of Applied Mechanics and Biomedical Engineering, Indian Institute of Technology Madras, Chennai, Tamil Nadu 600036, India.

Biomicrofluidics
|October 2, 2023
PubMed
Summary

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This summary is machine-generated.

Bio-inspired microfluidics leverage nature's designs for advanced "on-chip" systems. Future research integrates AI and machine learning for personalized disease models and faster drug development.

Area of Science:

  • Biomicrofluidics
  • Bio-inspired engineering
  • Microfluidic systems

Background:

  • Biomicrofluidics draws inspiration from natural biological systems.
  • Translating biological functionalities into artificial microfluidic systems presents significant challenges.
  • Progress requires integrating experimental and simulation approaches at the engineering-biology interface.

Purpose of the Study:

  • To review recent advancements in bio-inspired microfluidic systems.
  • To discuss the development and applications of "on-chip" technologies.
  • To explore future research directions for creating human physiological replicas on biochips.

Main Methods:

  • Integration of experimental and computational simulation tools.
  • Review of "on-chip" technology development, applications, and fabrication advancements.

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  • Exploration of data-driven modeling (AI, machine learning) combined with physics-based paradigms.
  • Main Results:

    • Significant progress in bio-inspired microfluidic systems has been achieved.
    • "On-chip" technologies and their applications are expanding.
    • Advancements in materials and fabrication are enabling more sophisticated systems.

    Conclusions:

    • Future research should focus on merging AI/ML with physics-based models for realistic human physiological replicas.
    • These advanced biochips can revolutionize disease modeling and drug development.
    • This approach promises expedited drug screening while minimizing animal and human trials.