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Association of prothrombin complexe concentrate with venous thrombosis after cardiac surgery: a case-control study

Qiaowei Zheng1, Liting Zhang1, Tingting Liu1

  • 1Department of Pharmacy, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.

Frontiers in Cardiovascular Medicine
|October 2, 2023
PubMed

Insights

Perioperative prothrombin complex concentrate (PCC) infusion in cardiac surgery did not show a significant association with increased risk of postoperative venous thrombosis. Further randomized controlled trials are recommended to confirm these findings.

Area of Science:

  • Cardiology
  • Hematology
  • Surgical Outcomes

Background:

  • Prothrombin complex concentrate (PCC) is used to enhance coagulation and control bleeding.
  • The association between perioperative PCC infusion and venous thrombosis after cardiac surgery requires further investigation.

Purpose of the Study:

  • To assess the association between perioperative prothrombin complex concentrate (PCC) infusion and the risk of postoperative venous thrombosis in patients undergoing cardiac surgery.

Main Methods:

  • A case-control study was conducted involving 161 patients who underwent cardiac surgery in 2021.
  • Multivariate logistic regression and stratified analysis were employed to evaluate the correlation between PCC infusion and venous thrombosis, adjusting for confounders.

Main Results:

  • Of 161 patients, 37 (23.0%) developed venous thrombosis.
  • Initial analysis indicated a significantly increased risk of venous thrombosis with PCC infusion (OR: 3.10), but this association was not significant after adjusting for confounders (Model 2 OR: 1.76, P=0.3317).
  • A marginally significant association was observed in the fully adjusted model (Model 3 OR: 0.03, P=0.0637).

Conclusions:

  • Perioperative PCC infusion in cardiac surgery is not significantly associated with an increased risk of postoperative venous thrombosis.
  • Further randomized controlled trials are necessary to establish a definitive causal relationship.
Abstract

Keywords:
bleedingcardiac surgerycase-control studyprothrombin complex concentratevenous thrombosis

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