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Related Experiment Videos

The changing mammogram. A primary indication for needle localization biopsy.

M C Wilhelm, E S de Paredes, T Pope

    Archives of Surgery (Chicago, Ill. : 1960)
    |November 1, 1986
    PubMed
    Summary

    Changes in mammograms over time are a key indicator for breast cancer biopsies. These interval mammographic changes can reveal significant pathology, including invasive cancers and benign breast disease, underscoring their importance in early detection.

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    Area of Science:

    • Radiology
    • Oncology
    • Pathology

    Background:

    • Screening mammography improves breast cancer detection and survival rates.
    • Interval mammographic changes are frequently observed and may indicate underlying breast pathology.

    Purpose of the Study:

    • To evaluate the diagnostic significance of interval mammographic changes as an indication for breast biopsy.
    • To compare cancer detection rates and cancer subtypes between biopsies for initial mammographic abnormalities and interval changes.

    Main Methods:

    • Retrospective analysis of 452 needle localization biopsies performed for microcalcifications, mass, asymmetric density, or combinations thereof.
    • Analysis of interval mammographic changes as an indication for biopsy in a subset of patients.
    • Comparison of cancer prevalence and invasive cancer proportions between the two groups.

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    Main Results:

    • Mammography-detected abnormalities led to cancer diagnosis in 21% of cases.
    • Interval mammographic changes led to cancer diagnosis in 17.9% of cases.
    • Invasive cancers were less frequent in the interval change group (34%) compared to the initial abnormality group (51%). Benign findings were common in the interval group (160/195), with significant hyperplasia/atypia in 35%.

    Conclusions:

    • Interval mammographic abnormalities are significant indicators of breast pathology and warrant biopsy.
    • While interval changes may detect fewer cancers overall, they are crucial for identifying significant lesions, including those with hyperplasia or atypia.