Related Experiment Video

Updated: Jul 15, 2025

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
12:40

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors

Published on: December 7, 2014

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Efficacy and Safety of RET-Specific Kinase Inhibitors in RET-Altered Cancers: A Systematic Review

Muhammad Ashar Ali1, Syed S Shah2, Rimsha Ali3

  • 1Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Cancer Investigation
|October 2, 2023
PubMed

Insights

Selpercatinib and pralsetinib are effective RET-specific kinase inhibitors for RET-altered tumors, showing high response rates and manageable side effects in most patients.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • The RET proto-oncogene encodes a receptor tyrosine kinase.
  • Selpercatinib and pralsetinib are FDA-approved RET-specific tyrosine kinase inhibitors (TKIs).

Conclusions:

  • Selpercatinib and pralsetinib demonstrate significant efficacy in patients with RET-altered tumors.
  • These RET-specific TKIs are generally well-tolerated, with a manageable safety profile.
Keywords:
RET-inhibitorRET-mutationSelpercatiniblung cancermeta-analysissystematic reviewthyroid cancer

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