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Summary
Benign sexual headache (BSH), a vascular type of headache, occurred in four sisters. Propranolol hydrochloride prophylaxis successfully treated the most affected sister, suggesting BSH may be a migraine variant.
Area of Science:
- Neurology
- Genetics
Background:
- Benign sexual headache (BSH) is a primary headache disorder.
- The vascular type of BSH has been rarely reported, with limited understanding of its etiology.
- Familial occurrence of medical conditions can provide insights into genetic predispositions.
Purpose of the Study:
- To describe a familial occurrence of the vascular type of benign sexual headache.
- To review the literature on sexual activity-related headaches.
- To formulate the clinical features of BSH and propose its classification.
Main Methods:
- Case report of a family with four affected sisters.
- Review of existing literature on headaches associated with sexual activity.
- Clinical assessment and treatment of affected individuals.
Main Results:
- A family cluster of vascular BSH was identified in four sisters.
- The most severely affected sister showed successful response to propranolol hydrochloride prophylaxis.
- Clinical features of BSH were systematically reviewed and defined.
Conclusions:
- Familial occurrence supports a potential genetic link or shared environmental factors in BSH.
- The vascular type of BSH is proposed as a variant of migraine.
- Propranolol hydrochloride may be an effective prophylactic treatment for BSH.