[Main variables of carbohydrate metabolism in elderly men-northerners.]

Aging normally leads to profound changes in the homeostasis of carbohydrate metabolism, which is considered a good predictor of health state and life expectancy. The objective of this study was assessing main indicators of carbohydrate metabolism in Northern men of older ages living under conditions of the North-Eastern region of Russia (Magadan). The results of the study showed carbohydrate disorders in healthy elderly men who exhibited high values of fasting plasma glucose (5,81±0,20 mmol/L) and glycosylated hemoglobin (5,73±0,12%), mainly owing to elevated insulin resistance (HOMA-IR was 2,63±0,25 arb. units), and not to reduced pancreatic β-cells function (HOMA-β was 96,85±6,10%), in the absence of a compensatory increase in basal insulin levels (9,97±0,81 µm/mL). Carbohydrate metabolism tenduence in healthy elderly men appears to worsen cardiometabolic health in older residents of the North. Our data confirm those by other authors and indicate the formation of age-associated pathology that causes accelerated aging of the body.