Related Experiment Video

Updated: Jul 15, 2025

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
08:08

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

Published on: May 11, 2015

14.2K

Bronchopulmonary dysplasia - associated pulmonary hypertension: An updated review

Ahmed El-Saie1, Nidhy P Varghese2, Melissa K Webb3

  • 1Section of Neonatology, Department of Pediatrics, Children's Mercy Hospital, Kansas City, MO, USA.

Seminars in Perinatology
|October 2, 2023
PubMed

Insights

Bronchopulmonary dysplasia (BPD) with pulmonary hypertension (PH) is a severe complication of prematurity. This review summarizes recent advances in preventing and managing BPD-PH to improve infant outcomes.

Area of Science:

  • Neonatology
  • Pediatric Pulmonology
  • Cardiology

Background:

  • Bronchopulmonary dysplasia (BPD) is the primary chronic lung disease in premature infants, with increasing incidence due to improved neonatal survival.
  • Pulmonary hypertension (PH) is a severe complication of BPD, affecting nearly one-third of infants with moderate to severe BPD.
  • Current treatments for BPD-PH show suboptimal responses, highlighting the need for novel management strategies.

Approach:

  • This review synthesizes current knowledge on the pathogenesis and pathophysiology of BPD-PH.
  • It details diagnostic approaches for identifying BPD-PH in affected infants.
  • The review summarizes existing and emerging treatment strategies for BPD-PH.

Key Points:

  • Advances in neonatal care increase survival but maintain high BPD incidence.
  • Pulmonary hypertension significantly elevates morbidity and mortality in BPD infants.
  • Effective prevention and management of BPD-PH require updated understanding and novel interventions.

Conclusions:

  • A comprehensive understanding of BPD-PH pathogenesis, diagnosis, and treatment is crucial.
  • Developing new therapeutic strategies is essential to improve outcomes for infants with BPD-PH.
  • Multidisciplinary collaboration is key to advancing the care of preterm infants with BPD-PH.

Keywords:
Bronchopulmonary dysplasiaDiagnosisManagementPathogenesisPulmonary hypertension

More Related Videos

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

114
Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet09:22

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Published on: November 4, 2015

12.3K

Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
207
Chronic Obstructive Pulmonary Disease-V: Nursing Management01:30

Chronic Obstructive Pulmonary Disease-V: Nursing Management

Nursing management of Chronic Obstructive Pulmonary Disease (COPD) is crucial for providing thorough care and support to patients. Nurses play an integral role in this process through detailed assessment, careful planning, targeted interventions, and ongoing evaluation. Here's an overview of the critical steps in nursing management for COPD.
Assessment
3.9K
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
263
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
249
Pulmonary Embolism III: Nursing Management01:27

Pulmonary Embolism III: Nursing Management

A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
15
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
353