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Pharmacotherapy of BPD: Current status & future perspectives

Rita M Ryan1, Devashis Mukherjee1, Stephanie Ford1

  • 1UH Rainbow Babies & Children's Hospital and Case Western Reserve University, Cleveland, OH.

Seminars in Perinatology
|October 2, 2023
PubMed

Insights

Bronchopulmonary dysplasia (BPD) treatments face challenges due to inconsistent efficacy and side effects. This review covers current and emerging therapies for BPD and related pulmonary hypertension.

Area of Science:

  • Neonatology
  • Pulmonology
  • Pharmacology

Background:

  • Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting premature infants, with evolving definitions since 1967.
  • Despite extensive research, few drugs are routinely used for BPD due to inconsistent clinical trial results and adverse effects.

Approach:

  • This review synthesizes data from numerous clinical and animal studies on BPD therapies.
  • It focuses on commonly used drugs and novel treatments targeting BPD and BPD-related pulmonary hypertension (BPD-PH).

Key Points:

  • Many BPD therapies show limited or inconsistent efficacy in human trials.
  • Emerging treatments offer potential but are not yet standard care.
  • BPD-related pulmonary hypertension (BPD-PH) is a critical complication addressed by some therapies.

Conclusions:

  • There is a need for more effective and safer treatments for BPD.
  • Further research and clinical trials are essential to validate new BPD therapies.
  • Optimizing management of BPD and BPD-PH remains a priority in neonatal care.

Keywords:
CaffeineMesenchymal stem cellsSildenafilSteroidsVitamin A

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