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Enhancing dendritic cells by inhibiting BCL2

Christopher A G Booth1, Andrew A Lane1

  • 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Trends in Cancer
|October 2, 2023
PubMed

Dendritic cells play an important role in anticancer immunity by exposing T cells to tumor-associated antigens. In a recent study, Zhao et al. show that BCL2 inhibition improves the ability of dendritic cells to present antigen to T cells and activate their antitumor cytotoxicity.

Keywords:
BCL2 inhibitiondendritic cellsimmunotherapy

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