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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

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Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
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Combinatorial interventions in aging.

Andrey A Parkhitko1, Elizabeth Filine2, Marc Tatar3

  • 1Aging Institute of UPMC and the University of Pittsburgh, Pittsburgh, PA, USA. aparkhitko@pitt.edu.

Nature Aging
|October 2, 2023
PubMed
Summary
This summary is machine-generated.

Combining interventions targeting aging pathways can extend lifespan and healthspan more effectively than single treatments. These combined approaches may offer new therapeutic strategies for age-related diseases.

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Area of Science:

  • Gerontology and aging research
  • Molecular biology of aging
  • Genetics of longevity

Background:

  • Understanding aging mechanisms is crucial for extending healthspan and treating age-related diseases.
  • Single interventions (monotherapy) show limited efficiency in extending longevity.
  • Limited data exists on the combined effects of aging interventions.

Purpose of the Study:

  • To summarize interactions between age-related pathways.
  • To discuss strategies for simultaneously targeting multiple aging pathways.
  • To explore the potential of combined interventions for healthspan and lifespan extension.

Main Methods:

  • Review and synthesis of existing literature on aging pathways and interventions.
  • Analysis of interactions between different genetic and pharmacological manipulations.
  • Examination of effects on hallmarks of aging and lifespan across different organisms.

Main Results:

  • Combined manipulations can additively impact common aging hallmarks and lifespan, suggesting shared pathway participation.
  • Interactions between interventions targeting different hallmarks can independently maximize effects on lifespan and healthy aging.
  • Most interaction studies are in invertebrates, with varying translatability to humans.

Conclusions:

  • Simultaneous targeting of multiple aging pathways offers a promising strategy for enhancing longevity and healthspan.
  • Conserved pro-longevity pathways present opportunities for identifying druggable targets for human age-associated pathologies.
  • Combined interventions may provide a more efficient approach to combatting aging and its related diseases.