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Involvement of the systemic microcirculation in pediatric uveitis
Carlyn V Kouwenberg1, Julia Spierings2, Evianne L de Groot3
1Department of Ophthalmology, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, The Netherlands. C.V.Kouwenberg-3@umcutrecht.nl.
Pediatric Rheumatology Online Journal
|October 2, 2023
Summary
Pediatric uveitis affects systemic microcirculation, with changes varying by subtype. Nailfold capillaroscopy revealed differences in capillary density and morphology in children with uveitis compared to controls.
Area of Science:
- Ophthalmology
- Pediatric Rheumatology
- Microcirculation Research
Background:
- Pediatric uveitis is a serious eye condition causing vision loss.
- Retinal microcirculation is affected in intermediate and panuveitis.
- Systemic microcirculation in pediatric uveitis is underexplored.
Purpose of the Study:
- To investigate systemic microcirculation in children with uveitis.
- To compare nailfold capillaroscopy (NFC) findings in pediatric uveitis patients and healthy controls.
Main Methods:
- Nailfold capillaroscopy (NFC) performed on 119 children with noninfectious uveitis and 25 healthy controls.
- Assessed capillary density, dilated capillaries, avascular areas, microhemorrhages, and capillary morphology.
- Regression analysis adjusted for age and sex to compare NFC parameters.
Main Results:
- Pediatric uveitis cases showed significantly more dilated capillaries and ramified capillaries than controls.
- Intermediate uveitis cases had more dilated capillaries.
- Anterior uveitis cases had lower capillary density and more ramified capillaries.
Conclusions:
- Children with uveitis, even without systemic disease, exhibit altered systemic microcirculation.
- Microcirculatory changes identified via NFC differ across pediatric uveitis subtypes.
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