Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interaction between flurazepam and ethanol.

W Y Hu, R J Reiffenstein, L Wong

    Alcohol and Drug Research
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Third-trimester prenatal brain imaging for early diagnosis of glutaric aciduria type 1 in monochorionic diamniotic twins.

    Hong Kong medical journal = Xianggang yi xue za zhi·2026
    Same author

    INVESTIGATING FACTORS INFLUENCING THE AMOUNT OF INJECTION PAIN IN THE ORAL CAVITY: A SYSTEMATIC REVIEW.

    Georgian medical news·2025
    Same author

    Longitudinal fetal growth parameters in women at high risk for pre-eclampsia.

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
    Same author

    Prediction of pre-eclampsia using maternal hemodynamic parameters at 12 + 0 to 15 + 6 weeks.

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
    Same author

    Consolidated and updated ultrasonographic fetal biometry and estimated fetal weight references for the Hong Kong Chinese population.

    Hong Kong medical journal = Xianggang yi xue za zhi·2024
    Same author

    The clinical meaning and significance of OVEMP morphology.

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2024
    Same journal

    Sex-differences in ethanol sensitivity and alcohol and aldehyde dehydrogenase activities in the Syrian hamster.

    Alcohol and drug research·1987
    Same journal

    Disassociation of cerebellar phospholipid composition and acute ethanol effects in mice selectively bred for differential sensitivity to ethanol.

    Alcohol and drug research·1987
    Same journal

    Inhibition of voluntary ethanol intake in rats by a combination of dihydroergotoxine and thioridazine.

    Alcohol and drug research·1987
    Same journal

    Demonstration of a threshold concentration for ethanol at the time of regaining the righting response in long-sleep and short-sleep mice.

    Alcohol and drug research·1987
    Same journal

    Chronotropic and inotropic effects on atria of chronic ethanol ingestion in the aging rat.

    Alcohol and drug research·1987
    Same journal

    Ethanol and aging effects on movement initiation can be dissociated from general behavioral impairment using a high-speed lever-release task in rats.

    Alcohol and drug research·1987
    See all related articles

    Combining benzodiazepines like flurazepam with ethanol increases accident risk due to synergistic effects on motor skills and behavior. However, the risk of fatal overdose remains low.

    Area of Science:

    • Pharmacology
    • Toxicology
    • Neuroscience

    Background:

    • Benzodiazepines and ethanol are commonly used substances.
    • Understanding their combined effects is crucial for public health and safety.

    Purpose of the Study:

    • To investigate the interaction between flurazepam (a benzodiazepine) and ethanol in mice.
    • To assess the combined effects on various behavioral and physiological endpoints, including sedation, motor coordination, anesthesia, and lethality.

    Main Methods:

    • Experiments were conducted on ICR albino mice.
    • Standardized tests were used to measure rotarod performance, light and deep sedation, loss of righting reflex, anesthesia, and lethality.
    • Dose-response relationships were analyzed using isobolograms to determine drug interactions (synergism, antagonism, or no interaction).

    Related Experiment Videos

    Main Results:

    • Synergistic interactions were observed in motor and behavioral tests (rotarod performance, light sedation, deep sedation, loss of righting reflex), particularly at higher ethanol doses.
    • Little to no interaction was found for anesthesia and lethality endpoints.
    • The degree of synergism varied across different tests and doses of ethanol.

    Conclusions:

    • Concurrent use of benzodiazepines and ethanol can significantly increase the risk of accidents in humans due to enhanced motor impairment and behavioral effects.
    • While behavioral synergism is evident, the risk of fatal overdose from simple combined overdose appears to be minimal.
    • These findings highlight the importance of caution when combining these substances.