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Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
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Dying for a cause: The pathogenic manipulation of cell death and efferocytic pathways

Kelley N Cooper1,2, Jan Potempa2,3, Juhi Bagaitkar4,5

  • 1Department of Immunology and Microbiology, University of Louisville, Louisville, Kentucky, USA.

Molecular Oral Microbiology
|October 3, 2023
PubMed

Insights

Cell death pathways eliminate pathogens and prime immunity. However, pathogens evade these crucial antimicrobial defenses, including oral pathogens, impacting host persistence.

Area of Science:

  • Immunology
  • Microbiology
  • Cell Biology

Background:

  • Cell death was traditionally viewed as beneficial to pathogens.
  • Emerging evidence reveals cell death pathways as a sophisticated antimicrobial strategy.
  • These pathways eliminate pathogens while stimulating immune responses.

Purpose of the Study:

  • To provide an overview of regulated cell death and efferocytic pathways.
  • To discuss pathogen evasion strategies targeting these pathways.
  • To highlight the role of oral pathogens in evading cell death.

Main Methods:

  • Literature review of cell death and efferocytosis.
  • Analysis of pathogen virulence strategies.
  • Case studies of pathogen-host interactions.

Main Results:

  • Cell death pathways are crucial for pathogen clearance and immune priming.
  • Phagocytosis of dead cells by antigen-presenting cells enhances adaptive immunity.
  • Pathogens, including oral pathogens, have evolved diverse mechanisms to evade cell death.

Conclusions:

  • Regulated cell death is a complex host defense mechanism.
  • Pathogen evasion of cell death is a significant factor in host persistence.
  • Understanding these interactions is vital for developing new therapeutic strategies.
Keywords:
P. gingivalisapoptosisefferocytosisnecroptosisperiodontitispyroptosis

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