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Related Experiment Videos

Development of context-specific tolerance to morphine: support for a dual-process interpretation.

M S Paletta, A R Wagner

    Behavioral Neuroscience
    |October 1, 1986
    PubMed
    Summary

    Rats developed context-specific tolerance to morphine

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Morphine, a potent analgesic and sedative, can induce tolerance.
    • Tolerance to drugs can be influenced by environmental cues.
    • A dual-process model suggests both general and specific conditioned responses contribute to tolerance.

    Purpose of the Study:

    • To investigate the development of context-specific tolerance to morphine's effects in rats.
    • To examine the temporal course of morphine-induced activity changes and analgesia.
    • To determine if tolerance to morphine is influenced by environmental context.

    Main Methods:

    • Four experiments were conducted with rats.
    • Morphine was administered acutely to assess baseline effects.
    • Rats were repeatedly exposed to morphine in a distinctive environment to assess tolerance development.
    • Activity levels and analgesic responses were measured.

    Main Results:

    • Tolerance to morphine's sedating and analgesic effects was observed.
    • Evidence for context-specific tolerance was found.
    • Conditioned compensatory responses were detected in the activity measure but not in the analgesic measure.
    • The activity measure exhibited a biphasic response to morphine, unlike the analgesic measure.

    Conclusions:

    • Tolerance to morphine can be specific to the environmental context in which it is administered.
    • The development of conditioned compensatory responses may depend on the nature of the unconditioned response.
    • Findings support a dual-process model of drug tolerance, incorporating both general and specific conditioned effects.

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