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Updated: Jul 15, 2025
09:56
Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
Published on: August 2, 2016
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Novel biotin-linked amphiphilic calix[4]arene-based supramolecular micelles as doxorubicin carriers for boosted
Dan Du1,2, Yu-Dun Liu1,2, Jun-Bing Lan1,2
1College of Pharmacy, Xuzhou Medical University, Xuzhou 221004, P. R. China.
Chemical Communications (Cambridge, England)
|October 3, 2023
Abstract:
Supramolecular carrier-mediated chemotherapy is a highly attractive strategy for targeted drug delivery. In this study, four novel biotin-linked calix[4]arenes BPCA1-BPCA4 have been rationally designed to construct nano-complex with doxorubicin. The in vitro and in vivo assessments reveal that BPCA4-DOX with excellent stability are capable of affording significantly superior anti-tumor activity and lower side effects.
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