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Related Experiment Video

Updated: Jul 15, 2025

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Published on: November 27, 2019

Metabolic changes with intermittent fasting.

Maria G Lange^1,2, Alice A Coffey¹, Paul C Coleman¹

¹Warwick Medical School, University of Warwick, Coventry, UK.

Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association

|October 3, 2023

Summary

This summary is machine-generated.

Intermittent fasting aids weight loss and fat reduction, comparable to continuous calorie restriction. However, its effects on glucose and lipid metabolism require further investigation.

Keywords:

alternate day fasting intermittent fasting obesity weight loss

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Area of Science:

Nutrition Science
Metabolic Health
Weight Management

Background:

Global rise in obesity necessitates effective weight management strategies.
Intermittent fasting (IF) is gaining attention as a lifestyle intervention for obesity.
Healthcare professionals and the public show increasing interest in IF.

Purpose of the Study:

To review the impact of intermittent fasting on metabolic indices.
To synthesize evidence from systematic reviews published between 2011 and 2022.

Main Methods:

Rapid review methodology.
PubMed database search for systematic reviews.
Inclusion of studies published from 2011 to 2022.

Main Results:

Intermittent fasting (IF) promotes weight loss, similar to continuous energy restriction.
IF generally leads to greater fat loss compared to ad libitum diets.
Evidence on IF's impact on insulin resistance, glucose, and lipid profiles is mixed.
Ramadan fasting shows temporary metabolic improvements and weight loss.

Conclusions:

Intermittent fasting is effective for weight management, outperforming ad libitum intake and matching continuous energy restriction.
Clinical benefits of IF on glucose and lipid metabolism remain inconclusive.
Further research is needed to clarify IF's long-term metabolic effects.