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Updated: Jul 15, 2025

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
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Use of Diuretics and Risk of Acute Angle Closure: A Case-Control Study.

Grace L Qiao1, Frederick S Mikelberg1, Mahyar Etminan2

  • 1Department of Ophthalmology and Visual Sciences, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

Ophthalmic Epidemiology
|October 3, 2023
PubMed
Summary
This summary is machine-generated.

This study found no increased risk of acute angle closure (AAC) associated with diuretic use. These findings suggest diuretics are not a significant risk factor for AAC development.

Keywords:
Acute angle closurecase-control studydiureticsdrug safety

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Area of Science:

  • Ophthalmology
  • Pharmacology
  • Epidemiology

Background:

  • Diuretics are commonly prescribed medications.
  • Acute angle closure (AAC) is a serious ophthalmic condition.
  • The potential link between diuretic use and AAC requires investigation.

Purpose of the Study:

  • To investigate the association between diuretic use and the risk of developing acute angle closure (AAC).

Main Methods:

  • A nested case-control study was conducted using the PharMetrics Plus database (2006-2020).
  • Cases of AAC were identified using ICD-9/10 codes.
  • Matched controls were selected, and conditional logistic regression was used to calculate rate ratios (RRs), adjusting for confounding medications.

Main Results:

  • The study analyzed 713,574 diuretic users, identifying 1,553 AAC cases and 6,212 controls.
  • No significant increase in AAC risk was observed with the use of all diuretics combined (RR=1.06).
  • Specific diuretic classes (thiazides, loop, potassium-sparing) also showed no significant association with increased AAC risk.

Conclusions:

  • The findings indicate no elevated risk of acute angle closure (AAC) among patients using diuretics.
  • Further research is warranted to corroborate these results and understand the implications for clinical practice.