UK Haemoglobin Disorders Peer Review: A Quality Standards-based review programme for sickle cell disease and

S Chakravorty1, E Drasar2, B Kaya3

  • 1King's College Hospital NHS Trust, London, UK.

PubMed

Insights

Peer reviews initially improved healthcare quality for haemoglobinopathy patients in the UK. However, sustained improvement was not achieved, highlighting a need for better support for these specialized services.

Area of Science:

  • Healthcare Quality Improvement
  • Patient Care Management
  • Clinical Governance

Background:

  • Haemoglobinopathy services require continuous quality improvement.
  • Peer review is a common strategy for enhancing healthcare standards.

Purpose of the Study:

  • To assess the long-term impact of Quality Standards (QS)-based peer reviews on haemoglobinopathy care in the UK.
  • To evaluate the effectiveness of peer review programs in driving sustained healthcare quality improvements.

Main Methods:

  • Analysis of compliance data from four QS-based peer reviews conducted between 2010 and 2020.
  • Inclusion of data from 17-33 paediatric and 29-32 adult haemoglobinopathy centres per review cycle.
  • Evaluation of participant feedback alongside compliance metrics.

Main Results:

  • Significant improvement in QS compliance was observed between the first two peer review cycles.
  • No significant improvement in QS compliance was noted in the final review programme (2018/2020).
  • Haemoglobinopathy departments showed less capacity to implement critical peer review recommendations compared to other disease groups.

Conclusions:

  • The peer review program did not consistently drive sustained improvements in healthcare quality for haemoglobinopathy.
  • There is a clear need for enhanced development and ongoing support for haemoglobinopathy services within the National Health Service.
  • Further research is required to understand variations in the effectiveness of peer review initiatives across different disease specialities.

Related Concept Videos

Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Hemoglobin01:24

Hemoglobin

Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Jaundice01:25

Jaundice

Jaundice, or icterus, is the yellow discoloration of the skin, sclerae, and mucous membranes. It happens when plasma bilirubin levels rise above 2.5-3 mg/dL, leading to bilirubin deposition in tissue.Bilirubin is a byproduct of hemoglobin degradation. In macrophages, hemoglobin breaks down into globin and heme. Globin is converted into amino acids, while heme is turned into biliverdin by heme oxygenase, which is then reduced to unconjugated bilirubin by biliverdin reductase.Unconjugated...