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Methadone, pentobarbital, pimozide and ethanol-intake.
Alcohol (Fayetteville, N.Y.)
|September 1, 1986
Summary
Rats increased sweetened ethanol solution intake when given methadone or pentobarbital. Naloxone antagonized pentobarbital
Area of Science:
- Pharmacology and neuroscience
Background:
- Rats voluntarily consume sweetened ethanol solutions.
- Understanding factors influencing ethanol intake is crucial for addiction research.
Purpose of the Study:
- To investigate the effects of methadone, pentobarbital, pimozide, and naloxone on ethanol intake in rats.
Main Methods:
- Rats were water-deprived and given daily access to ethanol solution (ES) or water.
- Administered methadone, pentobarbital, pimozide, or naloxone at various doses and timings.
- Measured ES intake and observed drug effects.
Main Results:
- Methadone and pentobarbital increased ES intake, with specific doses affecting only ES consumption.
- Pimozide did not alter ES intake.
- Naloxone dose-dependently blocked pentobarbital's effect on increasing ES intake.
Conclusions:
- Methadone and pentobarbital can increase ethanol consumption in rats.
- Naloxone exhibits an antagonistic effect on pentobarbital-induced ethanol intake.
- These findings contribute to understanding drug interactions and ethanol consumption mechanisms.